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GLP-1 medications have demonstrated cardiovascular benefits beyond weight loss alone in clinical trials making hypertensive patients with elevated BMI a well-supported candidate population

[369] demonstrated that somatic hypermutation rates are similar in both young and elderly individuals, suggesting that the increased number of mutations in Ig genes seen in older adults [370] likely results from cumulative exposure over time rather than an inherently altered mutation process

And a 2023 analysis3 of 61 clinical trials found that semaglutide produced the greatest blood pressure reduction of any medication studied

Some patients may need concurrent statin therapy

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